Effect of abdominoplasty in the lipid profile of patients with dyslipidemia.

Introduction. Dyslipidemia like other chronic degenerative diseases is pandemic in Latin America and around the world. A lot of patients asking for body contouring surgery can be sick without knowing it. Objective. Observe the lipid profile of patients with dyslipidemia, before and three months after an abdominoplasty. Methods. Patients candidate to an abdominoplasty without morbid obesity were followed before and three months after the surgery. We compared the lipid profile, glucose, insulin, and HOMA (cardiovascular risk marker) before and three months after the surgery. We used Student's t test to compare the results. A P value less than 0.05 was considered as significant. Results. Twenty-six patients were observed before and after the surgery. At the third month, we found only statistical differences in LDL and triglyceride values (P 0.04 and P 0.03). The rest of metabolic values did not reach statistical significance. Conclusion. In this group of patients with dyslipidemia, at the third month, only LDL and triglyceride values reached statistical significances. There is no significant change in glucose, insulin, HOMA, cholesterol, VLDL, or HDL.

[Clinical research X. Usefulness of an organic mesh in the repair of abdominal defects]. / Reparación del defecto herniario. Empleo de malla de material orgánico.

OBJECTIVE: to measure the compliance, security and usefulness of organic mesh (bovine pericardium) in the repair of abdominal defect in an animal model. METHODS: Wistar rats (weight 300 to 500 g), were anesthetized and an abdominal defect of 1 cm in each animal was performed. Animals were divided according to the repair material used: bovine pericardium mesh (n = 6) and polipropilene mesh (n = 6). Animals were sacrificed on day 28 after the surgery. Presence of infection, necrosis and adherences (macroscopic and microscopic) were compared. Tensile force was also measured in both groups. RESULTS: inflammation, necrosis and adherences were similar in both groups. The prolene mesh (mean rupture force 66.5 joules) was stronger than bovine pericardium (mean rupture force 47.4 joules) p = 0.002, however, had also more adherences. CONCLUSIONS: there is no difference between inflammation, necrosis and adherences. But the polipropilene mesh was stronger than the bovine pericardium mesh. This finding could have relevance in the clinical practice (hernia recurrence).

Resultados en el manejo de quemaduras eléctricas en un hospital de tercer nivel / Results in the management of electrical burns at a third level health care hospital

Objetivo: Demostrar si existe diferencia en los resultados del manejo de pacientes con quemaduras por electricidad de alto y bajo voltaje en el Antiguo Hospital Civil de Guadalajara y comparar nuestros resultados con lo publicado en la literatura. Sede: Antiguo Hospital Civil ''Fray Antonio Alcalde'' (tercer nivel de atención). Diseño: Estudio descriptivo y retrospectivo. Análisis estadístico: Para el análisis de variables no paramétricas se utilizó la prueba de χ² y para variables paramétricas la prueba t de Student, considerando estadísticamente significativo un valor de p ≤ a 0.05. Pacientes y métodos: Pacientes con quemaduras por electricidad en el periodo del 1 de enero del 2010 al 31 de diciembre del 2010. Se incluyeron todos los pacientes con quemaduras por electricidad y se dividieron en dos grupos: grupo I, pacientes con quemaduras por alto voltaje y grupo II, pacientes con quemaduras de bajo voltaje. Las variables estudiadas fueron edad, sexo, ocupación, estado civil, tipo de quemadura (alto o bajo voltaje), sitio de entrada, sitio de salida, tiempo entre la lesión y la llegada a urgencias, porcentaje de superficie corporal quemada, tratamiento establecido, volumen urinario, mioglobinuria, procedimientos quirúrgicos, días de estancia hospitalaria y mortalidad. Resultados: Se incluyeron un total de 22 pacientes adultos, 19 hombres y 3 mujeres. El grupo I incluyó 8 pacientes y el grupo II 14 pacientes. Todos los pacientes llegaron al servicio de urgencias dentro de las primeras 24 horas posteriores al accidente. Los pacientes con quemaduras por alto voltaje presentaron mayor estancia hospitalaria (p 0.0035). Se presentó únicamente una muerte, perteneciente al grupo I. Conclusión: Las quemaduras por alto voltaje confieren mayor morbimortalidad y mayor estancia hospitalaria.

Objective: To demonstrate whether there is a difference in the results of handling patients with high or low voltage-induced burns treated at the Antiguo Hospital Civil de Guadalajara and to compare our results with those in the literature. Setting: Antiguo Hospital Civil ''Fray Antonio Alcalde'' (third level health care hospital). Design: Descriptive, retrospective study. Statistical analysis: χ2 square test was used for non-parametric variables and Student's t test was used for parametric variables. Statistical significance was set at p ≤ than 0.05. Patients and methods: Patients with electrical burns cared for from January 1, 2010 to December 31, 2010. All patients with electrical burns were included and were divided in two groups: group I, those with high voltage burns, and group II those with low voltage burns. Variables studied were: age, sex, occupation, civil status, type of burn (high or low voltage), entrance site, exit site, time elapsed between injury and arrival to the emergency care, percentage of burnt body surface, established treatment, urinary volume, myoglobinuria, surgical procedures, days of in-hospital stay, and mortality. Results: A total of 22 adult patients were included, 19 men and 3 women. Group I consisted of 8 patients and group II of 14 patients. All patients arrived at the emergency ward within the first 24 hours after the accident. Patients with high-voltage burns had longer in-hospital stays (p 0.0035). There was only one death, pertaining to group I. Conclusion: High voltage burns lead to greater morbidity and mortality, and to a longer in-hospital stay.

[Systemic steroids use in second degree burn using an animal model]. / Esteroides sistémicos en quemaduras de segundo grado. Uso en un modelo animal.

BACKGROUND: the use of steroids is recognized in septic shock. There are reports of their use in burns. It is also known their negative effect in wound healing. OBJECTIVE: to know the effect of steroids in burn healing. METHODS: two groups of ten rats (wistar) were exposed to metallic cylinder at 95°C for 15 seconds on the back. At the moment of the burn one group received hydrocortisone dose 5 mg/kg. The other group didn't received medication. The scar was removed at the fifth day and the burn injury was covered with queratinocyte culture. The rats were sacrificed at 14th day. The presence of infection and the percentage of new epithelium, fibrosis, inflammatory process, presence of fibroblast and vascular proliferation were evaluated. We compared both groups using χ(2) test. RESULTS: there are no difference between groups in fibrosis, inflammatory process, or fibroblast presence. But there is a difference in vascular proliferation against the first group (steroid group). There were no signs of infection and all of them were epithelized at the 14th day. CONCLUSIONS: the use of steroids in burns only showed difference in vascular proliferation.

Cambios en los niveles estriatales de glutamato y aspartato en un modelo de la corea de Huntington: prevención de la neurotoxicidad del ácido quinolínico por kinurenina y probenecid / Changes in the striatal levels of glutamate and aspartante in a Huntington chorea model: prevention of quinolinic acid induced neurotoxicity by kynurenine and probenecid

La kinurenina (KYN) es el metabolito precursor del antagonista de los receptores glutamatérgicos para N-metil-D-as-partato (NMDA), el ácido kinurénico (KYNA). Por su pate, el probenecid (PROB) bloquea la excreción del KYNA desde el fluido extracelular. El KYNA antagoniza la neurotoxicidad ácido quinolínico (QUIN), en el cerebro de mamíferos. En este trabajo evaluamos el efecto de la administración sistémica de KYN y del PROB por separado o en combinación, sobre el contenido estriatal de dos aminoácidos excitadores del sistema nervioso, los ácidos glutámico (Glu) y aspártico (Asp), después de la administración intraestriatal unilateral de QUIN (240 nmol/ml) a las ratas. Los contenidos estriales de Glu y Asp. Analizados por cromatografía de líquidos, se encontraron disminuidos en ratas lesionadas por QUIN al compararse contra valores control (-44 por ciento y -43 por ciento, respectivamente). Los cambios en las concentraciones de estos aminoácidos fueron parcial o totalmente prevenidos por la administración de los pretratamientos con KYN (150, 300 ó 450 mg/kg, i.p.) o PROB (100, 200 ó 300 mg/kg, i.p.) a las ratas 2 horas antes de la inyección del QUIN. La coadministración de ambos fármacos previno la pérdida estriatal de Glu y Asp mediada por QUIN. Por su parte, la administración de un conocido antagonista de los receptores para NMDA, la dizocilpina (MK-80 1, 10 mg/kg, i.p.) previno totalmente la disminución estriatal de ambos aminoácidos. Estos hallazgos sugieren un papel farmacológico de la KYN y del PROB como inductores del antagonismo del KYNA sobre los receptores para NMDA